The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

Obesity is a major global concern and is generally attributed to a combination of genetic and
environmental factors. Several hypotheses have been proposed to explain the evolutionary …

Background: Exploring the mechanisms of valvular heart disease at the cellular level may be
useful to identify new therapeutic targets; however, the comprehensive cellular landscape of …

The propeller-shaped blades of the PIEZO1 and PIEZO2 ion channels partition into the
plasma membrane and respond to indentation or stretching of the lipid bilayer, thus …

Abstract Type 1 diabetes (T1D) is a metabolic disease commonly affecting adolescents and
causing various health complications. Corn silk (CS), a traditional Chinese medicine with …

Simple Summary Immune-cell activation is triggered upon antigen or target recognition. This
is modulated by co-stimulatory or co-inhibitory signals provided by the cellular environment …

Sertoli cells, omnipresent, somatic cells within the seminiferous tubules of the mammalian
testis are essential to male fertility. Sertoli cells maintain the integrity of the testicular …

Single-cell multi-Omics (SCM-Omics) and spatial multi-Omics (SM-Omics) technologies
provide state-of-the-art methods for exploring the composition and function of cell types in …

Type 1 diabetes (T1D) is an organ-specific autoimmune disease caused by pancreatic β cell
destruction and mediated primarily by autoreactive CD8+ T cells. It has been shown that …

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum
(ER)-resident secretory protein that reduces inflammation and promotes proliferation in …