To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

Traditional cell culture and animal models utilized for preclinical drug screening have led to
high attrition rates of drug candidates in clinical trials due to their low predictive power for …

Regulation of cosmetic testing and poor predictivity of preclinical drug studies has spurred
efforts to develop new methods for systemic toxicity. Current in vitro assays do not fully …

The outer blood–retinal barrier (oBRB) tightly controls the transport processes between the
neural tissue of the retina and the underlying blood vessel network. The barrier is formed by …

Over the past decade, organ-on-chip research has been one of the most prolific areas of the
entire field of tissue engineering. The development of organ-on-chip models requires an …

Humans and other animals are exposed to a wide array of man-made toxicants, many of
which act as endocrine disruptors that exhibit differential effects across the lifespan. In …

The goal of human‐on‐a‐chip systems is to capture multiorgan complexity and predict the
human response to compounds within physiologically relevant platforms. The generation …

Disruption of tissue barriers formed by cells is an integral part of the pathophysiology of
many diseases. Therefore, a thorough understanding of tissue barrier function is essential …

Organs-on-chips are microphysiological in vitro models of human organs and tissues that
rely on culturing cells in a well-controlled microenvironment that has been engineered to …

A microfluidic multi-organ chip emulates the tissue culture microenvironment, enables
interconnection of organ equivalents and overcomes interspecies differences, making this …