Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …

G‐quadruplexes are secondary structures formed in G‐rich sequences in DNA and RNA.
Considerable research over the past three decades has led to in‐depth insight into these …

Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …

Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …

Summary G-quadruplex (G4) is an important type of nucleic acid secondary structure. An
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …

EGFR tyrosine kinase inhibitors have made remarkable success in targeted cancer therapy.
However, therapeutic resistance inevitably occurred and EGFR-targeting therapy has been …

Nucleic acid aptamers are single-stranded DNA or RNA molecules identified to recognize
with high affinity specific targets including proteins, small molecules, ions, whole cells and …

We describe a sequence-based computational model to predict DNA G-quadruplex (G4)
formation. The model was developed using large-scale machine learning from an extensive …

Nucleic acids (DNA and RNA) dynamically fold and unfold to exert their functions in cells.
These folding and unfolding behaviours are also the basis for various technical applications …

Guanine (G)-quadruplexes (G4s) are unique nucleic acid structures that are formed by
stacked G-tetrads in G-rich DNA or RNA sequences. G4s have been reported to play …