Harnessing plant biosynthesis for the development of next-generation therapeutics

P Spence, J Reed, A Osbourn - PLoS biology, 2024 - journals.plos.org
Harnessing plant biosynthesis for the development of next-generation therapeutics | PLOS
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Chemoproteomics approach to elucidating biosynthetic pathway of plant natural products

Q Yin, M Yang - Frontiers in Plant Science, 2024 - frontiersin.org
Natural products derived from medicinal plants are a class of compounds with extensive
biological activities, playing a crucial role in the pharmaceutical, food, and cosmetics …

[HTML][HTML] De Novo Synthesis of Anticholinergic Hyoscyamine and Scopolamine in Nicotiana benthamiana Based on Elucidating Tropane Alkaloid Biosynthetic Pathway …

M Wen, J Zeng, F Qiu, F Zhang, Z Liao - Agronomy, 2024 - mdpi.com
Anisodus luridus, a perennial herb belonging to the genus Anisodus of the Solanaceae
family, is an important Tibetan medicinal plant that produces pharmaceutical tropane …

Biosynthesis and Bioactivity of Anti-Inflammatory Triterpenoids in Calendula officinalis (pot marigold)

D Golubova, M Salmon, H Su, C Tansley… - bioRxiv, 2025 - biorxiv.org
Plants have been central to traditional medicine for millennia, yet the precise metabolites
responsible for their therapeutic properties often remain unidentified. Moreover, the low …

Localising enzymes to biomolecular condensates increases their accumulation and benefits engineered metabolic pathway performance in Nicotiana benthamiana

AL Lindstrom Battle, AW Barrett, MD Fricker… - bioRxiv, 2025 - biorxiv.org
Establishment of N. benthamiana as a robust biofactory is complicated by issues such as
product toxicity and proteolytic degradation of target proteins/introduced enzymes. Here we …

Semi-automated workflow for high-throughput Agrobacterium-mediated plant transformation

D Annese, F Romani, C Grandellis, L Ives… - bioRxiv, 2024 - biorxiv.org
High-throughput experiments in plants are hindered by long generation times and high
costs. To address these challenges, we present an optimized pipeline for Agrobacterium …