Indigo production identifies hotspots in cytochrome P450 BM3 for diversifying aromatic hydroxylation
DJ Fansher, JN Besna, JN Pelletier - Faraday Discussions, 2024 - pubs.rsc.org
Evolution of P450 BM3 is a topic of extensive research, but screening the various
substrate/reaction combinations remains a time-consuming process. Indigo production has …
substrate/reaction combinations remains a time-consuming process. Indigo production has …
Concluding Remarks: Biocatalysis
UT Bornscheuer - Faraday Discussions, 2024 - pubs.rsc.org
Biocatalysis is a rapidly evolving field with increasing impact in organic synthesis, chemical
manufacturing and medicine. The Faraday Discussion reflected the current state of …
manufacturing and medicine. The Faraday Discussion reflected the current state of …
Design of a genetically programmable and customizable protein scaffolding system for the hierarchical assembly of robust, functional macroscale materials
R Zhang, S Kang, FJ Gaascht, EL Pena… - bioRxiv, 2024 - biorxiv.org
Inspired by the properties of natural protein-based biomaterials, protein nanomaterials are
increasingly designed with natural or engineered peptides, or with protein building blocks …
increasingly designed with natural or engineered peptides, or with protein building blocks …
Selective Oxidation of Vitamin D3 Enhanced by Long‐Range Effects of a Substrate Channel Mutation in Cytochrome P450BM3 (CYP102A1)
W Chen, JNC Lynch, C Bustamante, Y Zhang… - … –A European Journal - Wiley Online Library
Vitamin D deficiency affects nearly half the population, with many requiring or opting for
supplements with vitamin D3 (VD3), the precursor of vitamin D (1α, 25‐dihydroxyVD3). 25 …
supplements with vitamin D3 (VD3), the precursor of vitamin D (1α, 25‐dihydroxyVD3). 25 …
Indigo Formation as a Predictor of Substrate Promiscuity in Cytochrome P450 BM3 Libraries
D Valikhani, JN Besna, O Rousseau… - 2024 - chemrxiv.org
Cytochrome P450 BM3 natively exhibits substrate promiscuity, mainly in hydroxylation and
epoxidation reactions. Whereas directed evolution has broadened its scope of reactivity …
epoxidation reactions. Whereas directed evolution has broadened its scope of reactivity …