Sepsis is a life-threatening clinical syndrome caused by infection. Its pathogenesis is
complex and entails coagulation dysfunction, inflammation, and immune disorders …

Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Despite the widespread use of the blockade of immune checkpoints, for a significant number
of cancer patients, these therapies have proven ineffective, presumably due to the …

Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated
immune responses and multiple organ dysfunction. The imbalance between …

Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …

Simple Summary Inflammation is like the proverbial double-edged sword. Controlled short-
term inflammation could be a protective response while uncontrolled inflammation sustains …

Many cancers possess the ability to suppress the immune response to malignant cells, thus
facilitating tumour growth and invasion, and this has fuelled research to reverse these …

Immune cells of the monocyte/macrophage lineage are characterized by their diversity,
plasticity, and variety of functions. Among them, macrophages play a central role in antiviral …

Alternatively activated macrophages (M2 polarization) play an important role in asthma.
Short-chain fatty acids (SCFAs) possessed immune-regulatory functions, but their effects on …

The balance between M1 and M2 macrophage polarization is involved in the regulation of
pulmonary inflammation. Nuclear factor erythroid-derived 2-like 2 (Nfe2l2, also known as …