Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however,
many patients with migraine do not benefit from drugs that antagonize the CGRPergic …

Abstract Purpose of Review Despite advances in orthopedics, there remains a need for
therapeutics to hasten fracture healing. However, little focus is given to the role the nervous …

During evolution, the development of bone was critical for many species to thrive and
function in the boundary conditions of Earth. Furthermore, bone also became a storehouse …

Abstract Purpose of Review Fractures are a prominent form of traumatic injury and shall
continue to be for the foreseeable future. While the inflammatory response and the cells of …

Abstract Purpose of Review The traditionally understated role of neural regulation in fracture
healing is gaining prominence, as recent findings underscore the peripheral nervous …

Migraine is a debilitating neurological disorder impacting millions worldwide. Calcitonin
Gene-Related Peptide (CGRP) has emerged as a key player in migraine pathophysiology …

Abstract Purpose of Review This review examines the diverse functional relationships that
exist between the peripheral nervous system (PNS) and bone, including key advances over …

Aim: To determine the mechanism of Calcitonin gene-related peptide (CGRP) in bone
healing. Materials & methods: Alkaline phosphatase (ALP) activity and inflammatory-factor …

Beyond the sensation of pain, peripheral nerves have been shown to play crucial roles in
tissue regeneration and repair. As a highly innervated organ, bone can recover from injury …

Osteoarthritis represents a chronic degenerative joint disease with exceptional clinical
relevance. Polymorphisms of the CALCA gene, giving rise to either a procalcitonin/calcitonin …