Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

Activation of LXR activity by synthetic agonists has been the focus of many drug discovery
efforts with a focus on treatment of dyslipidemia and atherosclerosis. Many agonists have …

Hyperlipidemia and increased circulating cholesterol levels are associated with increased
cardiovascular disease risk. The liver X receptors (LXRs) are regulators of de novo …

Background This study was designed to investigate whether differential DNA methylationin
of cholesterol absorption candidate genes can function as a biomarker for patients with …

Diastereoselective reactions supported by metals and nonmetals offer a multifaceted path
for the synthesis of robust intermediates of value to academia and industry. The reactions …

Non-alcoholic fatty liver disease (NAFLD) is a major public health problem worldwide, with
an increasing incidence, secondary to the increasing incidence of obesity and diabetes …

Abstract A type of 2, 2‐disubstituted N‐sulfonylaziridines bearing OTBS groups and aryl
groups at two different substitutions of the aziridine ring has been prepared. Based on them …

Insulin resistance induced by a high-fat diet (HFD) is related to metabolic diseases, and
sterol O-acyltransferase 1 (SOAT1) is a key enzyme for the biosynthesis of cholesteryl ester …

An enantio-and regioselective organocatalytic cascade starting from isatin has been
disclosed to construct tetrahydrofuranyl spirooxindoles in high yields and stereoselectivities …

Abstract An efficient Fe (ClO4) 3⋅ 6H2O‐promoted hetero‐Pictet‐Spengler reaction has
been developed, enabling divergent approaches to plenty of structurally diverse …