Head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous group of
tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and …

Abstract PD-1/PD-L1 blockade therapy is a promising cancer treatment strategy, which has
revolutionized the treatment landscape of malignancies. Over the last decade, PD-1/PD-L1 …

PURPOSE In extensive-disease small-cell lung cancer (ED-SCLC), response rates to first-
line platinum-based chemotherapy are robust, but responses lack durability. CheckMate …

Tumors responding to immune checkpoint inhibitors (ICIs) have a higher level of immune
infiltrates and/or an Interferon (IFN) signature indicative of a T-cell-inflamed phenotype …

Background This study aimed to assess the safety and tolerability of the immune checkpoint
inhibitor nivolumab, as monotherapy or combined with chemotherapy, in Japanese patients …

Colorectal cancer (CRC), as a prominent cause of cancer-related deaths, has historically
been notable worldwide and many attempts have been made to raise the overall survival of …

Background–The presence of tumor-infiltrating lymphocytes (TILs) in the tumor
microenvironment is associated with an improved prognosis and a better response to …

The programmed death protein 1 (PD-1) and its ligand (PD-L1) represent a well-
characterized immune checkpoint in cancer, effectively targeted by monoclonal antibodies …

Anti-programmed cell death protein 1 (PD-1) agents have become the standard of care for
platinum-refractory recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) …

Tumor-draining lymph nodes (LNs) play a crucial role during cancer spread and in initiation
of anti-cancer adaptive immunity. Neutrophils form a substantial population of cells in LNs …