Advanced treatments based on immune system manipulation, gene transcription and
regulation, specific organ and cell targeting, and/or photon energy conversion have …

Rheumatoid arthritis (RA) is one of the most common chronic autoimmune diseases. Despite
considerable advances in clinical treatment of RA, suboptimal response to therapy and …

Simple Summary Solid cancers are surrounded by a network of non-cancerous cells
comprising different cell types, including fibroblasts, and acellular protein structures. This …

Cancer is a complex disease with high incidence and mortality rates. The important role
played by the tumor microenvironment in regulating oncogenesis, tumor growth, and …

Simple Summary Intestinal inflammation leads to an increased risk of developing colorectal
cancer (CRC) and incidences are expected to rise. Therefore, it is crucial to identify …

Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or BM-40, is a
matricellular protein which regulates cell adhesion, extracellular matrix production, growth …

Aim Resistance to neoadjuvant chemoradiotherapy (NCRT) and tumor recurrence presents
a major clinical problem in locally advanced rectal cancer (LARC) patients. This study aimed …

Introduction: Lung cancer is still the leading cause of cancer among cancer patients.
Although there are novel therapies as second line treatment for NSCLC, there is an issue for …

Background Osteomimicry of cancer cells had been widely reported in prostate cancer and
breast cancer. However, the prognostic value of osteomimicry in various cancer types …

Colorectal cancer (CRC) is the second most deadly cancer globally, and 30% of these
cancers occur in the rectum. The primary treatment for CRC is surgery, often radiotherapy …