[PDF][PDF] tRNA renovatio: Rebirth through fragmentation

B Kuhle, Q Chen, P Schimmel - Molecular Cell, 2023 - cell.com
Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …

Blood-based biomarkers for eosinophilic esophagitis and concomitant atopic diseases: a look into the potential of extracellular vesicles

E Grueso-Navarro, P Navarro… - International Journal of …, 2023 - mdpi.com
Eosinophilic esophagitis (EoE) is a chronic, Th2-inflammatory disease of the esophagus that
can severely affect food intake. Currently, diagnosis and assessing response to treatment of …

Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs

S Park, J Ham, C Yang, W Park, H Park… - Journal of Pineal …, 2023 - Wiley Online Library
Endometriosis is a benign gynecological disease characterized by abnormal growth of
endometrial‐like cells outside the uterus. Melatonin, a hormone secreted by the pineal …

Urinary exosome tsRNAs as novel markers for diagnosis and prediction of lupus nephritis

S Chen, X Zhang, K Meng, Y Sun, R Shu… - Frontiers in …, 2023 - frontiersin.org
Objective Lupus nephritis (LN) is one of the most severe organ manifestations of systemic
lupus erythematosus (SLE). Early identification of renal disease in SLE is important. Renal …

Single-read tRNA-seq analysis reveals coordination of tRNA modification and aminoacylation and fragmentation

X Hernandez-Alias, CD Katanski, W Zhang… - Nucleic Acids …, 2023 - academic.oup.com
Transfer RNA (tRNA) utilizes multiple properties of abundance, modification, and
aminoacylation in translational regulation. These properties were typically studied one-by …

Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay

S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar… - Nature …, 2022 - nature.com
Oligodendrocytes are specialized cells that confer neuronal myelination in the central
nervous system. Leukodystrophies associated with oligodendrocyte deficits and …

The tRNA‐derived fragment tRF‐24‐V29K9UV3IU functions as a miRNA‐like RNA to prevent gastric cancer progression by inhibiting GPR78 expression

H Wang, W Huang, X Fan, X He, S Chen… - Journal of …, 2022 - Wiley Online Library
Emerging studies have proved that tRNA‐derived fragments (tRFs) play vital roles in tumor
metastasis; however, the function of tRFs in gastric cancer (GC) remains largely unclear. We …

Noncoding RNAs and RNA-binding proteins: Emerging governors of liver physiology and metabolic diseases

C Sommerauer, C Kutter - American Journal of Physiology …, 2022 - journals.physiology.org
The liver holds central roles in detoxification, energy metabolism, and whole body
homeostasis but can develop malignant phenotypes when being chronically overwhelmed …

[HTML][HTML] Plasma exosomal tRNA‐derived fragments as diagnostic biomarkers in non-small cell lung cancer

B Zheng, X Song, L Wang, Y Zhang, Y Tang… - Frontiers in …, 2022 - frontiersin.org
Background: tRNA derived small RNAs (tRFs) have recently received extensive attention;
however, the effects of tRFs in exosome as biomarkers has been less studied. The objective …

Coordination of RNA modifications in the brain and beyond

AY Chen, MC Owens, KF Liu - Molecular Psychiatry, 2023 - nature.com
Gene expression regulation is a critical process throughout the body, especially in the
nervous system. One mechanism by which biological systems regulate gene expression is …