The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …

Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the
same peptide or protein has emerged in the past two decades as a major pathway for both …

Mammalian prions propagate as distinct strains and are composed of multichain assemblies
of misfolded host-encoded prion protein (PrP). Here, we present a near-atomic resolution …

Many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive appearance of abnormal …

The clinical and pathological differences between synucleinopathies such as Parkinson's
disease and multiple system atrophy have been postulated to stem from unique strains of α …

The clinical presentation and the pathological processes underlying Alzheimer's disease
(AD) can be very heterogeneous in severity, location, and composition including the amount …

Parkinson's disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive
diseases that feature a common neuropathological hallmark of aggregated α-synuclein …

Amyloid-β (Aβ) fibrils exhibit self-propagating, molecular-level polymorphisms that may
contribute to variations in clinical and pathological characteristics of Alzheimer's disease …

Accumulation of filamentous aggregates of tau protein in the brain is a pathological hallmark
of Alzheimer's disease (AD) and many other neurodegenerative tauopathies. The filaments …

Artificial nanoparticles accumulate a protein corona layer in biological fluids, which
significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses …