RB Dunlap, f NG L. Harding, t and FM Huennekens § abstract: Thymidylate synthetase has
been isolated from sonically disrupted cells of amethopterin-resistant Lactobacillus casei …

Extracts of dichloromethotrexate-resistant Lactobacillis casei provide a rich source of stable
thymidylate synthetase, showing 100 times the activity found in extracts of the sensitive …

Overproduction of microbial metabolites and enzymes due to alteration of regulation Page 1
CHAPTER 5 Overproduction of Microbial Metabolites and Enzymes Due to Alteration of …

A procedure is described for the isolation and crystallization of thymidylate synthetase from a
dichloromethotrexate resistant strain of Lactobacillus casei. The recrystallized enzyme …

Karel Slavik,* Wojciech Rode, and Vera Slavikova abstract: The adsorption of thymidylate
synthetase from Escherichia coli B to aminoalkyl-Sepharose with the in-creasing length of …

Publisher Summary The amounts of a particular enzyme produced by a particular
microorganism can vary tremendously because enzyme formation is regulated in both …

In the presence of thymidylate synthetase, 5, lO-methylenetetrahydrofolate donates its labile
one-carbon unit (the methylene group) to deoxyuridylate, and also provides the reducing …

Extracts of dichloromethotrexate-resistant Lacfobucillis casei provide a rich source of stable
thymidylate synthetase, showing 100 times the activity found in extracts of the sensitive …

Thymidylate synthetase is an enzyme of central importance in the metabollism of folates [1].
While the oxidation state of tetrahydrofolate is not altered by the action of most enzymes …

This chapter contains sections titled: Introduction Mechanism of Action Genetic Aspects of
Thymidylate Synthetase Regulatory Aspects of Thymidylate Synthetase Thymidylate …