Epigenetic mechanisms—including DNA methylation, histone post-translational
modifications and changes in nucleosome positioning—regulate gene expression, cellular …

The congenital myopathies are a group of early-onset, non-dystrophic neuromuscular
conditions with characteristic muscle biopsy findings, variable severity and a stable or slowly …

Several neurodegenerative diseases are caused by defects in protein folding, including
Alzheimer, Parkinson, Huntington, and prion diseases. Once a disease-specific protein …

The gut microbiota coevolves with its host, and numerous factors like diet, lifestyle, drug
intake and geographical location continuously modify its composition, deeply influencing …

Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people
worldwide. Growing evidence suggests that the gut microbiome (GM) plays a pivotal role in …

Aging is the leading risk factor for most chronic illnesses of old age, including Alzheimer
disease (AD), a progressive neurodegenerative disease with currently no therapies that …

This article reviews research results and ideas presented at a special symposium at the
International Association of Gerontology and Geriatrics (IAGG) Congress held in July 2017 …

Background Derailment of proteostasis, the homeostasis of production, function, and
breakdown of proteins, contributes importantly to the self‐perpetuating nature of atrial …

Accumulating evidence suggests that adversities at critical periods in early life, both pre-and
postnatal, can lead to neuroendocrine perturbations, including hypothalamic-pituitary …

To attain functionality, proteins must fold into their three-dimensional native state. The
intracellular balance between protein synthesis, folding, and degradation is constantly …