Nanobodies: next generation of cancer diagnostics and therapeutics

EY Yang, K Shah - Frontiers in Oncology, 2020 - frontiersin.org
The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

Prophylactic and therapeutic HPV vaccines: current scenario and perspectives

Y Mo, J Ma, H Zhang, J Shen, J Chen… - Frontiers in cellular …, 2022 - frontiersin.org
Persistent human papillomavirus (HPV) infection is recognized as the main cause of cervical
cancer and other malignant cancers. Although early detection and treatment can be …

Advances in HPV‐associated tumor management: therapeutic strategies and emerging insights

X Gong, H Chi, Z Xia, G Yang… - Journal of Medical …, 2023 - Wiley Online Library
With the rapid increase in the incidence of cervical cancer, anal cancer and other cancers,
human papillomavirus (HPV) infection has become a growing concern. Persistent infection …

Nanobodies in cancer

ER Verhaar, AW Woodham, HL Ploegh - Seminars in immunology, 2021 - Elsevier
For treatment and diagnosis of cancer, antibodies have proven their value and now serve as
a first line of therapy for certain cancers. A unique class of antibody fragments called …

Research progress and applications of nanobody in human infectious diseases

Y Mei, Y Chen, JP Sivaccumar, Z An, N Xia… - Frontiers in …, 2022 - frontiersin.org
Infectious diseases, caused by pathogenic microorganisms, are capable of affecting crises.
In addition to persistent infectious diseases such as malaria and dengue fever, the vicious …

A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants

N Pishesha, TJ Harmand… - Proceedings of the …, 2021 - National Acad Sciences
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has resulted in over 100 million infections and millions of deaths. Effective vaccines remain …

Nanobodies: the future of antibody-based immune therapeutics

NV Bathula, H Bommadevara… - Cancer biotherapy & …, 2021 - liebertpub.com
Targeted therapy is a fast evolving treatment strategy to reduce unwanted damage to
healthy tissues, while increasing efficacy and specificity. Driven by state-of-the-art …

In vivo detection of antigen-specific CD8+ T cells by immuno-positron emission tomography

AW Woodham, SH Zeigler, EL Zeyang, SC Kolifrath… - Nature …, 2020 - nature.com
The immune system's ability to recognize peptides on major histocompatibility molecules
contributes to the eradication of cancers and pathogens. Tracking these responses in vivo …

Aptamers as promising nanotheranostic tools in the COVID‐19 pandemic era

CKO Dzuvor, EL Tettey… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
The emergence of SARS‐COV‐2, the causative agent of new coronavirus disease (COVID‐
19) has become a pandemic threat. Early and precise detection of the virus is vital for …

Emerging applications of nanobodies in cancer therapy

RM Awad, F Meeus, H Ceuppens, T Ertveldt… - International review of …, 2022 - Elsevier
Cancer is a heterogeneous disease, requiring treatment tailored to the unique phenotype of
the patient's tumor. Monoclonal antibodies (mAbs) and variants thereof have enabled …