Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ
that has one of the highest metabolic rates body-wide and is constantly exposed to …

The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

Photoreceptors have high energy demands and a high density of mitochondria that produce
ATP through oxidative phosphorylation (OXPHOS) of fuel substrates. Although glucose is …

Acquired and inherited retinal disorders are responsible for vision loss in an increasing
proportion of individuals worldwide. Photoreceptor (PR) death is central to the vision loss …

The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and
have the highest density of mitochondria of any cell in the body. Both physiological and …

Axon degeneration can arise from metabolic stress, potentially a result of mitochondrial
dysfunction or lack of appropriate substrate input. In this study, we investigated whether the …

Diabetes can result in impaired corneal wound healing. Mitochondrial dysfunction plays an
important role in diabetic complications. However, the regulation of mitochondria function in …

Age-related macular degeneration (AMD) is a blinding eye disease, whose incidence
strongly increases with ages. The etiology of AMD is complex, including aging, abnormal …

Purpose: To determine if sleep deprivation induces dry eye through altering peroxisome
proliferator-activated receptor alpha (PPARα) expression in mice. Methods: The “stick over …

Synapses in the outer retina are the first information relay points in vision. Here,
photoreceptors form synapses onto two types of interneurons, bipolar cells and horizontal …