The multifunctional properties of astrocytes signify their importance in brain physiology and
neurological function. In addition to defining the brain architecture, astrocytes are primary …

Alzheimer's disease (AD) can increase the risk of epilepsy by up to 10‐fold compared to
healthy age‐matched controls. However, the pathological mechanisms that underlie this …

Though succinate accumulation is associated with reactive oxygen species (ROS)
production and neuronal injury, which play critical roles in epilepsy, it is unclear whether …

Refractory epilepsy is the main neurological manifestation of Alpers' syndrome, a severe
childhood-onset mitochondrial disease caused by bi-allelic pathogenic variants in the …

Adult neurogenesis is a striking example of neuroplasticity, which enables adaptive network
remodelling in response to all forms of environmental stimulation in physiological and …

Glutamine synthetase (GS) is an ATP-dependent enzyme found in most species that
synthesizes glutamine from glutamate and ammonia. In brain, GS is exclusively located in …

There is compelling evidence that initiation and maintenance of epileptic seizures in
temporal lobe epilepsy (TLE) is facilitated by excessive accumulation in the extracellular …

Abstract l-Glutamate is the predominant excitatory neurotransmitter in the central nervous
system (CNS) and is directly and indirectly involved in a variety of brain functions. Glutamate …

Epilepsy is a complex, multifactorial disease characterized by spontaneous recurrent
seizures and an increased incidence of comorbid conditions such as anxiety, depression …

Introduction Multiple lines of investigation have explored the role of glutamatergic and
purinergic systems in epilepsy, related cognitive impairment, and oxidative stress. Glutamate …