In recent years, the number of clinical trials in which adeno-associated virus (AAV) vectors
have been used for in vivo gene transfer has steadily increased. The excellent safety profile …

Bilirubin-Induced Neurologic Damage — Mechanisms and Management Approaches | New
England Journal of Medicine Skip to main content The New England Journal of Medicine …

Inherited disorders of hyperbilirubinemia may be caused by increased bilirubin production
or decreased bilirubin clearance. Reduced hepatic bilirubin clearance can be due to …

Inherited disorders of bilirubin metabolism might reduce bilirubin uptake by hepatocytes,
bilirubin conjugation, or secretion of bilirubin into bile. Reductions in uptake could increase …

Therapies for patients with myocardial infarction and heart failure are urgently needed, in
light of the breadth of these conditions and lack of curative treatments. To systematically …

Gilbert's syndrome (GS) is characterized by a benign, mildly elevated bilirubin concentration
in the blood. Recent reports show clear protection from cardiovascular disease in this …

Infants with chronic bilirubin encephalopathy often demonstrate abnormal bilateral,
symmetric, high-signal intensity on T2-weighted magnetic resonance imaging of the globus …

Crigler‐Najjar syndrome type I (CNSI) is a rare monogenic disease characterized by severe
neonatal unconjugated hyperbilirubinemia with a lifelong risk of neurological damage and …

Adeno-associated viruses (AAVs) are among the most efficient vectors for liver gene
therapy. Results obtained in the first hemophilia clinical trials demonstrated the long-term …

Unconjugated bilirubin is considered a potent antioxidant when present at moderate levels.
However, at high concentrations, it produces severe neurological damage and death …