[HTML][HTML] Renal normothermic machine perfusion: the road toward clinical implementation of a promising pretransplant organ assessment tool

TL Hamelink, B Ogurlu, J De Beule, VA Lantinga… - …, 2022 - journals.lww.com
The increased utilization of high-risk renal grafts for transplantation requires optimization of
pretransplant organ assessment strategies. Current decision-making methods to accept an …

Treatment of transplant kidneys during machine perfusion

SA Hosgood, M Hoff, ML Nicholson - Transplant International, 2021 - Wiley Online Library
The increasing use of donation after circulatory death (DCD) and extended criteria donor
(ECD) organs has raised awareness of the need to improve the quality of kidneys for …

The effect of hypothermic machine perfusion to ameliorate ischemia-reperfusion injury in donor organs

LWD Knijff, C van Kooten, RJ Ploeg - Frontiers in Immunology, 2022 - frontiersin.org
Hypothermic machine perfusion (HMP) has become the new gold standard in clinical donor
kidney preservation and a promising novel strategy in higher risk donor livers in several …

Kidney perfusion as an organ quality assessment tool—are we counting our chickens before they have hatched?

J De Beule, I Jochmans - Journal of Clinical Medicine, 2020 - mdpi.com
The final decision to accept an organ for transplantation remains a subjective one. With
“poor organ quality” commonly cited as a major reason for kidney discard, accurate …

[HTML][HTML] Brief O2 uploading during continuous hypothermic machine perfusion is simple yet effective oxygenation method to improve initial kidney function in a porcine …

T Darius, M Vergauwen, T Smith, I Gerin, V Joris… - American journal of …, 2020 - Elsevier
With oxygenation proposed as a resuscitative measure during hypothermic models of
preservation, the aim of this study was to evaluate the optimal start time of oxygenation …

Simply adding oxygen during hypothermic machine perfusion to combat the negative effects of ischemia-reperfusion injury: fundamentals and current evidence for …

T Darius, J Nath, M Mourad - Biomedicines, 2021 - mdpi.com
The use of high-risk renal grafts for transplantation requires optimization of pretransplant
preservation and assessment strategies to improve clinical outcomes as well as to decrease …

The role of metabolomics in current concepts of organ preservation

M Kvietkauskas, V Zitkute, B Leber, K Strupas… - International journal of …, 2020 - mdpi.com
In solid organ transplantation (Tx), both survival rates and quality of life have improved
dramatically over the last few decades. Each year, the number of people on the wait list …

Intermittent Surface Oxygenation Results in Similar Mitochondrial Protection and Maintenance of Aerobic Metabolism as Compared to Continuous Oxygenation during …

T Darius, M Vergauwen, L Maistriaux, R Evrard… - Journal of clinical …, 2023 - mdpi.com
Short bubble and subsequent surface oxygenation is an innovative oxygenation technique
and alternative for membrane oxygenation during hypothermic machine perfusion (HMP) …

Sevoflurane participates in the protection of rat renal ischemia‐reperfusion injury by down‐regulating the expression of TRPM7

X Xu, R Deng, L Zou, X Pan, Z Sheng… - Immunity …, 2023 - Wiley Online Library
Introduction To investigate the protective effect of sevoflurane preconditioning on renal
ischemia‐reperfusion injury (renalischemiareperfusionmodel, RIRI) and its related …

Evaluation of oxidative stress and metabolic profile in a preclinical kidney transplantation model according to different preservation modalities

S Mrakic-Sposta, A Vezzoli, E Cova… - International Journal of …, 2023 - mdpi.com
This study addresses a joint nuclear magnetic resonance (NMR) and electron paramagnetic
resonance (EPR) spectroscopy approach to provide a platform for dynamic assessment of …