PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
piRNA-guided genome defense: from biogenesis to silencing
PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins
constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial …
constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial …
PIWI-interacting RNA: its biogenesis and functions
YW Iwasaki, MC Siomi, H Siomi - Annual review of biochemistry, 2015 - annualreviews.org
PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are 24–31 nucleotides in
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …
Argonaute proteins: functional insights and emerging roles
G Meister - Nature Reviews Genetics, 2013 - nature.com
Small-RNA-guided gene regulation has emerged as one of the fundamental principles in
cell function, and the major protein players in this process are members of the Argonaute …
cell function, and the major protein players in this process are members of the Argonaute …
PIWI-interacting small RNAs: the vanguard of genome defence
PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that form the
piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …
piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …
Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state
A Le Thomas, AK Rogers, A Webster… - Genes & …, 2013 - genesdev.cshlp.org
In the metazoan germline, piwi proteins and associated piwi-interacting RNAs (piRNAs)
provide a defense system against the expression of transposable elements. In the …
provide a defense system against the expression of transposable elements. In the …
From guide to target: molecular insights into eukaryotic RNA-interference machinery
JJ Ipsaro, L Joshua-Tor - Nature structural & molecular biology, 2015 - nature.com
Since its relatively recent discovery, RNA interference (RNAi) has emerged as a potent,
specific and ubiquitous means of gene regulation. Through a number of pathways that are …
specific and ubiquitous means of gene regulation. Through a number of pathways that are …
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes
Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that
suppress transposons and enable gamete maturation. Mammalian transposon-silencing …
suppress transposons and enable gamete maturation. Mammalian transposon-silencing …
The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis
PIWI-family proteins and their associated small RNAs (piRNAs) act in an evolutionarily
conserved innate immune mechanism to provide essential protection for germ-cell genomes …
conserved innate immune mechanism to provide essential protection for germ-cell genomes …
Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines
PIWI-interacting RNAs (piRNAs) are endogenous small noncoding RNAs that act as
guardians of the genome, protecting it from invasive transposable elements in the germline …
guardians of the genome, protecting it from invasive transposable elements in the germline …