Viral infections are a leading cause of morbidity and mortality worldwide, and the importance
of public health practices including handwashing and vaccinations in reducing their spread …

The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …

Epidemiological studies have shown a dramatic increase in the incidence and the
prevalence of allergic diseases over the last several decades. Environmental triggers …

Background and Purpose Subarachnoid hemorrhage (SAH) is a life-threatening subtype of
stroke with high rates of mortality. In the early stages of SAH, neuroinflammation is one of the …

Abstract IL-9-producing CD4+ T cells have been considered to represent a distinct T helper
cell (TH cell) subset owing to their unique developmental programme in vitro, their …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

The prevalence of chronic immune and metabolic disorders is increasing rapidly. In
particular, inflammatory bowel diseases, obesity, diabetes, asthma and chronic obstructive …

Vitamin A (VA) is critical for many biological processes, including embryonic development,
hormone production and function, the maintenance and modulation of immunity, and the …

Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …

This Review explores the interplay between T cell activation and cell metabolism and
highlights how metabolites serve two pivotal functions in shaping the immune response …