The alpha-gal story: lessons learned from connecting the dots

JW Steinke, TAE Platts-Mills, SP Commins - Journal of Allergy and Clinical …, 2015 - Elsevier
Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal, and
therefore establishing its cause is pivotal to long-term risk management. Our recent work has …

Diagnosis and management of patients with the α-gal syndrome

TAE Platts-Mills, R Li, B Keshavarz, AR Smith… - The Journal of Allergy …, 2020 - Elsevier
The galactose-α-1, 3-galactose (α-Gal) syndrome has many novel features that are relevant
to diagnosis and management. In most cases, the diagnosis can be made on a history of …

Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients

SP Commins - Expert review of clinical immunology, 2020 - Taylor & Francis
ABSTRACT Introduction Alpha-gal Syndrome (AGS) is a unique allergy to non-primate
mammalian meat (and derived-products) that is associated with tick bites and is due to a …

Investigation into the α-gal syndrome: characteristics of 261 children and adults reporting red meat allergy

JM Wilson, AJ Schuyler, L Workman, M Gupta… - The Journal of Allergy …, 2019 - Elsevier
Background Red meat allergy has historically been understood as a rare disease of atopic
children, but the discovery of the “α-Gal syndrome,” which relates to IgE to the …

Allergy to furry animals: new insights, diagnostic approaches, and challenges

JR Konradsen, T Fujisawa, M Van Hage… - Journal of Allergy and …, 2015 - Elsevier
The prevalence of allergy to furry animals has been increasing, and allergy to cats, dogs, or
both is considered a major risk factor for the development of asthma and rhinitis. An …

[HTML][HTML] Particularities of allergy in the Tropics

L Caraballo, J Zakzuk, BW Lee, N Acevedo… - World Allergy …, 2016 - Elsevier
Allergic diseases are distributed worldwide and their risk factors and triggers vary according
to geographical and socioeconomic conditions. Allergies are frequent in the Tropics but …

Tick saliva and the alpha-gal syndrome: finding a needle in a haystack

SR Sharma, S Karim - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Ticks and tick-borne diseases are significant public health concerns. Bioactive molecules in
tick saliva facilitate prolonged blood-feeding and transmission of tick-borne pathogens to the …

Environmental and molecular drivers of the α-Gal syndrome

A Cabezas-Cruz, A Hodžić… - Frontiers in …, 2019 - frontiersin.org
The α-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody (Ab)
response against the carbohydrate Galα1-3Galβ1-4GlcNAc-R (α-Gal), which is present in …

Prevalence of type I sensitization to alpha‐gal in forest service employees and hunters

J Fischer, E Lupberger, J Hebsaker, G Blumenstock… - Allergy, 2017 - Wiley Online Library
Abstract Background The production of IgE molecules specific to the carbohydrate galactose‐
α‐1, 3‐galactose (alpha‐gal) is known to induce delayed anaphylaxis against mammalian …

Delayed anaphylaxis to red meat in patients with IgE specific for galactose alpha-1, 3-galactose (alpha-gal)

SP Commins, TAE Platts-Mills - Current allergy and asthma reports, 2013 - Springer
Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal. In
instances where the triggering allergen is not known, establishing the etiology of …