[HTML][HTML] Installing the “magic methyl”–C–H methylation in synthesis

D Aynetdinova, MC Callens, HB Hicks… - Chemical Society …, 2021 - pubs.rsc.org
The selective and efficient C–H methylation of sp2 and sp3 carbon centres has become a
powerful transformation in the synthetic toolbox. Due to the potential for profound changes to …

Research progress in electrochemical/photochemical utilization of methanol as a C1 source

HT Tang, YZ Pan, YM Pan - Green Chemistry, 2023 - pubs.rsc.org
Methanol is an important C1 source in organic synthesis because of its low cost, abundance,
and biodegradability. Therefore, using methanol as a C1 source to synthesize high-value …

Aminodealkenylation: Ozonolysis and copper catalysis convert C(sp3)–C(sp2) bonds to C(sp3)–N bonds

Z He, JA Moreno, M Swain, J Wu, O Kwon - Science, 2023 - science.org
Great efforts have been directed toward alkene π bond amination. In contrast, analogous
functionalization of the adjacent C (sp3)–C (sp2) σ bonds is much rarer. Here we report how …

Base Metal‐Catalyzed C‐Methylation Reactions Using Methanol

N Sarki, V Goyal, K Natte… - Advanced Synthesis & …, 2021 - Wiley Online Library
C‐methylation is a vitally important reaction applicable in chemical synthesis and structure‐
based drug design. Notably, the “magic methyl” effect has become decisive in medicinal …

Catalytically Generated Meerwein's Salt-Type Oxonium Ions for Friedel–Crafts C(sp2)–H Methylation with Methanol

T He, HFT Klare, M Oestreich - Journal of the American Chemical …, 2023 - ACS Publications
A catalytic protocol for a Friedel–Crafts-type direct C (sp2)–H methylation of various arenes
with methanol is disclosed. The reaction is initiated by counteranion-stabilized silylium or …

Recent Advancements in Typical Friedel–Crafts Alkylation Reactions Focused on Targeting Arene Nucleophiles

S Singh, CK Hazra - Synthesis, 2023 - thieme-connect.com
This review delves into recent advances and significant breakthroughs in the field of the
catalytic Friedel–Crafts alkylation of targeted arenes or heteroarenes. Though a few earlier …

[HTML][HTML] Electrochemical activation of C–H by electron-deficient W2C nanocrystals for simultaneous alkoxylation and hydrogen evolution

X Lin, SN Zhang, D Xu, JJ Zhang, YX Lin… - Nature …, 2021 - nature.com
The activation of C–H bonds is a central challenge in organic chemistry and usually a key
step for the retro-synthesis of functional natural products due to the high chemical stability of …

Copper-catalyzed C (sp3)–H methylation via radical relay

BC Figula, TA Chen, JA Bertke, TH Warren - ACS catalysis, 2022 - ACS Publications
The methyl moiety is a key functional group that can result in major improvements in the
potency and selectivity of pharmaceutical agents. We present a radical relay C–H …

Photovoltaic Materials as Heterogeneous Photocatalysts: A Golden Opportunity for Sustainable Organic Syntheses

G Sportelli, T Boselli, S Protti, N Serpone… - Solar RRL, 2023 - Wiley Online Library
Light absorption by semiconducting materials generates electrons and holes subsequent to
charge separation, which is at the core of two different applications: 1) photovoltaics and 2) …

N-Methylation of Amines with Methanol Catalyzed by Iridium(I) Complexes Bearing an N,O-Functionalized NHC Ligand

M González-Lainez, MV Jiménez, R Azpiroz… - …, 2022 - ACS Publications
A set of neutral [IrBr (L2)(κ C-tBuImCH2PyCH2OMe)] and cationic [Ir (L2)(κ2 C, N-
tBuImCH2PyCH2OMe)] PF6 (L2= cod,(CO) 2) Ir (I) compounds featuring a flexible lutidine …