Structure-guided identification of potential MTH1 inhibitors from natural compounds: toward therapeutic targeting of oxidative DNA damage in cancer

A Taiyab, T Mohammad, MN Sulaimani, F Anjum… - Chemical Papers, 2025 - Springer
Disrupted redox homeostasis and elevated ROS levels are linked to various diseases,
including cancer and neurodegenerative disorders. MutT homolog 1 (MTH1) is a critical …

Experimental diagnostic of sequence-variant dynamic perturbations revealed by broadband dielectric spectroscopy

L Bourgeat, L Pacini, A Serghei, C Lesieur - Structure, 2021 - cell.com
Genetic diversity leads to protein robustness, adaptability, and failure. Some sequence
variants are structurally robust but functionally disturbed because mutations bring the protein …

[HTML][HTML] A protocol to measure slow protein dynamics of the cholera toxin B pentamers using broadband dielectric spectroscopy

L Bourgeat, L Pacini, A Serghei, C Lesieur - STAR protocols, 2022 - Elsevier
The present protocol describes how to measure experimentally the slow protein dynamics
that take place upon the thermal unfolding of the B subunit cholera toxin pentamers using …

PhysChem 2019: RACI Australian Conference on Physical Chemistry, Perth, 11–14 February 2019

DA Wild - Australian Journal of Chemistry, 2020 - CSIRO Publishing
Duncan Wild received his Ph. D. degree from Melbourne University in 2003. He was an
Alexander von Humboldt and MPI Research Fellow at the MPI for Biophysical Chemistry in …

Etude expérimentale de la dynamique moléculaire des protéines: nouvelle méthode de criblages de conformations protéiques

L Bourgeat - 2020 - theses.hal.science
Les protéines sont des molécules fortement étudiées à causes de leurs différents rôles dans
les organismes vivants et de l'impact de leur disfonctionnement sur l'état de santé des …