The use of nanomedicine for antitumor therapy has been extensively investigated for a long
time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently …

The potent actions of pigment epithelium-derived factor (PEDF) on tumour-associated cells,
and its extracellular localization and secretion, stimulated research on this multifunctional …

Abstract mRNA delivery has shown high application value in the treatment of various
diseases, but its effective delivery is still a major challenge at present. Herein, we propose a …

Colorectal cancer is considered one of the major malignancies that threaten the lives and
health of people around the world. Patients with CRC are prone to post-operative local …

Colorectal cancer (CRC) is the third most common cancer worldwide, and metastatic CRC is
a fatal disease. The CRC-affected tissues show several molecular markers that could be …

Angiogenesis is naturally balanced by many pro-and anti-angiogenic factors while an
imbalance of these factors leads to aberrant angiogenesis, which is closely associated with …

Microvascular diseases are among the most clinically important diseases, and vascular
abnormalities are central in the development of such diseases. Pigment epithelium-derived …

TRAIL (tumour necrosis factor-related apoptosis-inducing ligand) gene therapy is
considered as one of the promising approaches for cancer treatment. Polyamidoamine …

For active cell targeting, viruses frequently capitalize on dual-receptor binding. With the
intention to mimic this natural process, a dual peptide-based approach for targeting cancer …

Background Co-delivery of anticancer drugs and gene is promising to generate synergistic
anticancer effects. Surface modification of nanocarriers with specific ligands could further …