Drug development for ischemic stroke is challenging as evidenced by the paucity of
therapeutics that have advanced beyond a phase III trial. There are many reasons for this …

Neurological disorders are a major global challenge, which counts for a substantial slice of
disease burden around the globe. In these, the challenging landscape of central nervous …

In this study, we investigated the potential of using curcumin (CUR) as an adjuvant to
enhance the delivery of antiretroviral drug elvitegravir (EVG) across the BBB, and alleviate …

Human immunodeficiency virus (HIV), which induces acquired immunodeficiency syndrome
(AIDS), is among the most lethal viral infections worldwide. Although the realm of highly …

Although antiretroviral therapy (ART) can suppress peripheral HIV, patients still suffer from
neuroHIV due to insufficient levels of ART drugs in the brain. Hence, this study focuses on …

In recent decades, there has been an increased interest in the development of intranasal
delivery systems for active pharmaceutical ingredients (APIs) not only for treating local nasal …

There are several safeguards in place to protect the brain from injury because of its
vulnerability. Two major barriers prevent harmful substances from entering the brain: the …