Synthetic biologists aim to construct novel genetic circuits with useful applications through
rational design and forward engineering. Given the complexity of signal processing that …

Synthetic Biology is the 'Engineering of Biology'–it aims to use a forward-engineering design
cycle based on specifications, modelling, analysis, experimental implementation, testing and …

Background Stomata are tiny pores in plant leaves that regulate gas and water exchange
between the plant and its environment. Abscisic acid and ethylene are two well-known …

Researchers working with mathematical models are often confronted by the related
problems of parameter estimation, model validation and model selection. These are all …

Ammonium assimilation in Escherichia coli is regulated by two paralogous proteins (GlnB
and GlnK), which orchestrate interactions with regulators of gene expression, transport …

Cellular signal transduction usually involves activation cascades, the sequential activation of
a series of proteins following the reception of an input signal. Here, we study the classic …

The last decade has seen an explosion in models that describe phenomena in systems
medicine. Such models are especially useful for studying signaling pathways, such as the …

We introduce a tensor-based clustering method to extract sparse, low-dimensional structure
from high-dimensional, multi-indexed datasets. This framework is designed to enable …

Ammonium assimilation in Escherichia coli is a model system of environmental sensing and
adaptation in bacteria. At the heart of it lies a cascade of covalent modification cycles …

Background: Stomata are tiny pores in plant leaves that regulate gas and water exchange
between the plant and its environment. Abscisic acid and ethylene are two well-known …