This review aims to provide an overview of the synthetic strategies employed for generating
modifications within the sugar backbone of nucleoside analogs. We have focused our …

Over the past decades, evidences have consistently shown that Neuroinflammation is a
critical underlying process in a range of CNS diseases, including neurodegenerative …

Mounting evidence indicates that alcohol-induced neuropathology may result from
multicellular responses in which microglia cells play a prominent role. Purinergic receptor …

With a growing interest of the involvement of extracellular nucleotides in both normal
physiology and pathology, it has become evident that P2 receptor agonists and antagonists …

Human immunodeficiency virus type 1 (HIV-1) causes a chronic infection that afflicts more
than 30 million individuals worldwide. While the infection can be suppressed with potent …

ABSTRACT HIV-1 Env glycoprotein-mediated fusion is initiated upon sequential binding of
Env to CD4 and the coreceptor CXCR4 or CCR5. Whereas these interactions are thought to …

ATP is a key energetic molecule, fundamental to cell function, which also has an important
role in the extracellular milieu as a signaling molecule, acting as a chemoattractant for …

Immune cell migration is required for the development of an effective and robust immune
response. This elegant process is regulated by both cellular and environmental factors, with …

Reviewers This article was reviewed by Neil S. Greenspan and Rachel Gerstein.
Nucleotides and nucleosides act as potent extracellular messengers via the activation of the …

Inflammatory bowel diseases are characterized by relapses and remission periods during
which numerous factors, including stress factors and nucleotides, are mobilized to re …