How aging and oxidative stress influence the cytopathic and inflammatory effects of SARS-CoV-2 infection: The role of cellular glutathione and cysteine metabolism
F Galli, G Marcantonini, D Giustarini, MC Albertini… - Antioxidants, 2022 - mdpi.com
SARS-CoV-2 infection can cause a severe respiratory distress syndrome with inflammatory
and thrombotic complications, the severity of which increases with patients' age and …
and thrombotic complications, the severity of which increases with patients' age and …
N-Acetylcysteine and its immunomodulatory properties in humans and domesticated animals
S Tieu, A Charchoglyan, L Paulsen… - Antioxidants, 2023 - mdpi.com
N-acetylcysteine (NAC), an acetylated derivative of the amino acid L-cysteine, has been
widely used as a mucolytic agent and antidote for acetaminophen overdose since the 1960s …
widely used as a mucolytic agent and antidote for acetaminophen overdose since the 1960s …
Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein
The development of small-molecules targeting different components of SARS-CoV-2 is a key
strategy to complement antibody-based treatments and vaccination campaigns in managing …
strategy to complement antibody-based treatments and vaccination campaigns in managing …
Strategies for the management of spike protein-related pathology
In the wake of the COVID-19 crisis, a need has arisen to prevent and treat two related
conditions, COVID-19 vaccine injury and long COVID-19, both of which can trace at least …
conditions, COVID-19 vaccine injury and long COVID-19, both of which can trace at least …
Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19
K Khanna, WW Raymond, J Jin… - … of Physiology-Lung …, 2022 - journals.physiology.org
The redox status of the cysteine-rich SARS-CoV-2 spike glycoprotein (SARS-2-S) is
important for the binding of SARS-2-S to angiotensin-converting enzyme 2 (ACE2) …
important for the binding of SARS-2-S to angiotensin-converting enzyme 2 (ACE2) …
Inhibition of the Cell Uptake of Delta and Omicron SARS-CoV-2 Pseudoviruses by N-Acetylcysteine Irrespective of the Oxidoreductive Environment
S La Maestra, S Garibaldi, R Balansky, F D'Agostini… - Cells, 2022 - mdpi.com
The binding of SARS-CoV-2 spikes to the cell receptor angiotensin-converting enzyme 2
(ACE2) is a crucial target both in the prevention and in the therapy of COVID-19. We …
(ACE2) is a crucial target both in the prevention and in the therapy of COVID-19. We …
Potential antiviral effects of pantethine against SARS-CoV-2
M Abou-Hamdan, R Saleh, S Mani, P Dournaud… - Scientific Reports, 2023 - nature.com
SARS-CoV-2 interacts with cellular cholesterol during many stages of its replication cycle.
Pantethine was reported to reduce total cholesterol levels and fatty acid synthesis and …
Pantethine was reported to reduce total cholesterol levels and fatty acid synthesis and …
[HTML][HTML] Potential antiviral effects of pantethine against SARS-CoV-2
B ML, A ML, F AS, DR Max - 2022 - europepmc.org
SARS-CoV-2 interacts with cellular cholesterol during many stages of its replication cycle.
Pantethine was reported to reduce total cholesterol levels and fatty acid synthesis and …
Pantethine was reported to reduce total cholesterol levels and fatty acid synthesis and …
N-Acetylcysteine (NAC) for COVID-19
J Santiano - drjessesantiano.com
Results The study found that the COVID-19 patients who took NAC had a significantly lower
risk of dying from COVID-19 despite having more significant comorbidities (Odds Ratio 0.56; …
risk of dying from COVID-19 despite having more significant comorbidities (Odds Ratio 0.56; …