Molecular mechanisms of obesity predisposes to atopic dermatitis

D Shang, S Zhao - Frontiers in Immunology, 2024 - frontiersin.org
Obesity is a prevalent metabolic disease that reduces bacterial diversity, colonizes the
epidermis with lipophilic bacteria, and increases intestinal pro-inflammatory species, all of …

Advances in the mechanism of action of short-chain fatty acids in psoriasis

Q Zhang, L Zhao, Y Li, S Wang, G Lu… - International …, 2024 - Elsevier
Psoriasis is a prevalent chronic inflammatory and immunological disorder. Its lesions are
present as scaly erythema or plaques. Disruptions in the body's immune system play a …

Apocrine Gland Damage and the Release of Specific Keratins in Early Stage Indicate the Crucial Involvement of Apocrine Glands in Hidradenitis Suppurativa

J Li, S Li, Q Zhang, M Liang, X Chen, Y Feng… - Journal of Investigative …, 2024 - Elsevier
The apocrine glands (AGs) are not considered to be primarily involved in hidradenitis
suppurativa (HS). This study investigated the potential role of AGs in HS pathogenesis using …

Psoriatic arthritis in psoriasis: optimizing the current screening system for psoriatic arthritis based on serum data from US and Chinese populations

Z Lin, S Pan, Y Shi, X Wu, Y Dou, P Lin… - Frontiers in …, 2024 - frontiersin.org
Background Psoriatic arthritis (PSA) is an inflammatory joint disease associated with
psoriasis (PSO) that can be easily missed. Existing PSA screening tools ignore objective …

Natural Product-Derived Compounds Targeting Keratinocytes and Molecular Pathways in Psoriasis Therapeutics

YG Lee, Y Jung, HK Choi, JI Lee, TG Lim… - International Journal of …, 2024 - mdpi.com
Psoriasis is a chronic autoimmune inflammatory skin disorder that affects approximately 2–
3% of the global population due to significant genetic predisposition. It is characterized by …

Distinct adaptive immune receptor feature of adipose-derived mesenchymal stem cells (AD-MSCs) treatment of psoriasis

L Tang, D Yao, Z He, S Ye, X Chen, Y Huang… - Archives of …, 2024 - Springer
Psoriasis (Ps) is one of the most common chronic inflammatory skin disorders with its
pathogenesis correlated with dysregulated innate and adaptive system. Even though …

[HTML][HTML] Determination of the FABP5 expression profile in skin lesions of an IMQ-induced psoriasis mouse model using flow cytometry

J Yu, J Hao, MS Yorek, X Han, A Avellino, X Jiang… - STAR protocols, 2024 - Elsevier
The fatty acid-binding protein 5 (FABP5) is a key player in psoriasis development. Therefore,
characterizing the expression profile of FABP5 in various cell types within both layers of …

FABP5 in Skin Macrophages Mediates Saturated Fat-Induced IL-1β Signaling in Obesity-Associated Psoriasis Development

J Yu, J Hao, MS Yorek, X Jiang, A Avellino, S Liu… - bioRxiv, 2024 - biorxiv.org
High fat diet (HFD)-induced obesity increases the risk and severity of psoriasis. However,
the immunoregulatory effects of different HFD-induced obesity on psoriasis pathogenesis …