Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

Many cell phenomena that involve shape changes are affected by the intrinsic deformability
of the plasma membrane (PM). Far from being a passive participant, the PM is now known to …

Mechanosensitive ion channels rely on membrane composition to transduce physical stimuli
into electrical signals. The Piezo1 channel mediates mechanoelectrical transduction and …

Atomic force microscopy (AFM)-based methods have matured into a powerful nanoscopic
platform, enabling the characterization of a wide range of biological and synthetic …

Biological processes rely on molecular interactions that can be directly measured using
force spectroscopy techniques. Here we review how atomic force microscopy can be applied …

Integrin-mediated mechanosensing of the extracellular environment allows cells to control
adhesion and signalling. Whether cells sense and respond to force immediately upon ligand …

The ability to sense and respond to mechanical stimuli emanates from sensory neurons and
is shared by most, if not all, animals. Exactly how such neurons receive and distribute …

Quantitative analysis of cellular interactions with the extracellular environment is necessary
to gain an understanding of how cells regulate adhesion in the development and …