Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

Wnt/β-catenin signaling is an evolutionarily conserved and versatile pathway that is known
to be involved in embryonic development, tissue homeostasis and a wide variety of human …

Detection of circulating tumor DNAs (ctDNAs) in cancer patients is an important component
of cancer precision medicine ctDNAs. Compared to the traditional physical and biochemical …

Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …

Over the last 20 years it has become clear that colorectal cancer (CRC) evolves through
multiple pathways. These pathways may be defined on the basis of two molecular …

Aberrant Wnt/β-catenin signaling is widely implicated in numerous malignancies, including
cancers of the gastrointestinal tract. Dysregulation of signaling is traditionally attributed to …

More than 20 years ago, the oncogenicity of a Wnt ligand was revealed in a series of
experiments originating with random proviral integration in mice. The significance of Wnt …

A deficient mismatch repair system (dMMR) is present in 10–20% of patients with sporadic
colorectal cancer (CRC) and is associated with a favourable prognosis in early stage …

The progress in our understanding of early events in the development of colonic neoplasia
is the result of 2 advances:(1) improved characterization of lesions detected at endoscopy …

In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the
adenomatous polyposis coli (APC) gene. Germline mutations cause familial adenomatous …