T. cruzi has a complex life cycle involving four developmental stages namely, epimastigotes,
metacyclic trypomastigotes, amastigotes and bloodstream trypomastigotes. Although …

The trypanosomatid (protozoan) parasites Trypanosoma cruzi and Leishmania spp. are
causative agents of Chagas disease and Leishmaniasis, respectively. They display high …

In the heart tissue of acutely Trypanosoma cruzi-infected mice miR-145-5p and miR-146b-
5p are, respectively, downregulated and upregulated. Here, we used the H9C2 rat …

SLC7A11 plays a pivotal role in tumour development by facilitating cystine import to
enhance glutathione synthesis and counteract oxidative stress. Disulphidptosis, an …

Prostate cancer (PCa) is a very prevalent male-specific malignancy; most PCa patients
eventually die as a result of metastasis. L-theanine (C7H14N2O3), a nonprotein amino acid …

Intracellular parasites from the genera Toxoplasma, Plasmodium, Trypanosoma,
Leishmania and from the phylum Microsporidia are, respectively, the causative agents of …

Introduction Trypanosoma cruzi, the causative agent of Chagas disease, can infect almost
any nucleated cell in the mammalian host. Although previous studies have described the …

ABSTRACT Phosphoinositide-3 kinase (PI3K) signaling regulates many cellular processes,
including cell survival, differentiation, proliferation, cytoskeleton reorganization, and …

Dendritic cells (DC) along with macrophages are the main host cells of the intracellular
parasite Leishmania. DC traverse a process of maturation, passing through an immature …

Trypanosoma cruzi cAMP-mediated invasion has long been described, however, the
detailed mechanism of action of the pathway activated by this cyclic nucleotide still remains …