Role of JAK/STAT in interstitial lung diseases; molecular and cellular mechanisms

P Montero, J Milara, I Roger, J Cortijo - International journal of molecular …, 2021 - mdpi.com
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …

Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis

K Kokubo, A Onodera, M Kiuchi, K Tsuji… - Frontiers in …, 2022 - frontiersin.org
Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host
defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 …

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

S Makaremi, A Asgarzadeh, H Kianfar… - Inflammation …, 2022 - Springer
A global pandemic has erupted as a result of the new brand coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated …

Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets

X Liu, W Xiong, M Ye, T Lu, K Yuan, S Chang… - … and Targeted Therapy, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has been looming globally for
three years, yet the diagnostic and treatment methods for COVID-19 are still undergoing …

Theophylline: Old drug in a new light, application in COVID-19 through computational studies

LM Montaño, B Sommer, JC Gomez-Verjan… - International Journal of …, 2022 - mdpi.com
Theophylline (3-methyxanthine) is a historically prominent drug used to treat respiratory
diseases, alone or in combination with other drugs. The rapid onset of the COVID-19 …

Interplay of opposing effects of the WNT/β-catenin pathway and PPARγ and implications for SARS-CoV2 treatment

A Vallee, Y Lecarpentier, JN Vallee - Frontiers in immunology, 2021 - frontiersin.org
The Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus SARS-CoV-2
(severe acute respiratory syndrome coronavirus 2), has quickly reached pandemic …

[HTML][HTML] The emerging role of miRNAs in the pathogenesis of COVID-19: Protective effects of nutraceutical polyphenolic compounds against SARS-CoV-2 infection

CY Yang, YH Chen, PJ Liu, WC Hu… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause
immunosuppression and cytokine storm, leading to lung damage and death. The clinical …

How aging and oxidative stress influence the cytopathic and inflammatory effects of SARS-CoV-2 infection: The role of cellular glutathione and cysteine metabolism

F Galli, G Marcantonini, D Giustarini, MC Albertini… - Antioxidants, 2022 - mdpi.com
SARS-CoV-2 infection can cause a severe respiratory distress syndrome with inflammatory
and thrombotic complications, the severity of which increases with patients' age and …

[HTML][HTML] MicroRNAs in the development of potential therapeutic targets against COVID-19: A narrative review

JQ Ahmed, SQ Maulud, M Dhawan… - Journal of Infection and …, 2022 - Elsevier
Background As the therapeutic regimens against the COVID-19 remain scarce, the
microRNAs (miRNAs) can be exploited to generate efficient therapeutic targets. The miRNAs …

The immune mechanism of the nasal epithelium in COVID-19–related olfactory dysfunction

S Chen, S Wang - Frontiers in Immunology, 2023 - frontiersin.org
During the first waves of the coronavirus disease 2019 (COVID-19) pandemic caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, olfactory …