Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

Chronic inflammation is a highly prevalent consequence of changes in environmental and
lifestyle factors that contribute to the development of cancer. The basis for this critical …

Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective
targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant …

The polybromo-associated PBAF (SWI/SNF) chromatin remodeling complex, which includes
PBRM1, ARID2, and BRD7, regulates cell differentiation and genomic integrity. MUC1-C is …

Abstract The Brg/Brahma-associated factor (BAF, mSWI/SNF) chromatin remodeling
complex is of importance in development and has been linked to prostate oncogenesis. The …

Background: Circular RNAs (circRNAs) have been identified as essential regulators in a
plethora of cancers. Nonetheless, the mechanistic functions of circRNAs in Renal Cell …

Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited treatment
options. TNBC progression is associated with expansion of cancer stem cells (CSCs). Few …

Mucins are a family of high-molecular-weight glycoproteins. MUC1 is widely studied for its
role in distinct types of cancers. In many human epithelial malignancies, MUC1 is frequently …

Abstract The polybromo-1 (PBRM1) chromatin-targeting subunit of the SWI/SNF PBAF
chromatin remodeling complex drives DNA damage resistance and immune evasion in …

Simple Summary The evidence reviewed here indicates that MUC1-C evolved in mammals
to promote inflammatory adaptation in barrier tissues that extends to resident stem cells and …