Impact of metformin on neocortical development during pregnancy: Involvement of ERK and p35/CDK5 pathways
Metformin, the most commonly prescribed drug for the treatment of diabetes, is increasingly
used during pregnancy to address various disorders such as diabetes, obesity …
used during pregnancy to address various disorders such as diabetes, obesity …
PI3K/Akt inhibition promotes AR activity and prostate cancer cell proliferation through p35-CDK5 modulation
Abstract Aberrant PI3K/Akt activation is linked to prostate cancer (PCa) malignancy, while
androgen receptor (AR) is critical in early-stage PCa development. Investigating the …
androgen receptor (AR) is critical in early-stage PCa development. Investigating the …
Metformin alters dendrite development and synaptic plasticity in rat cortical neurons
Synaptic plasticity is crucial as it dynamically molds the strength and connectivity of neural
circuits, influencing learning, memory, and the development of neurological disorders …
circuits, influencing learning, memory, and the development of neurological disorders …
Metformin inhibits nerve growth factor (NGF)-induced sympathetic neuron differentiation through p35/CDK5 inhibition
The authors' previous research has shown the pivotal roles of Cyclin-dependent kinase 5
(CDK5) and its regulatory protein p35 in nerve growth factor (NGF)-induced differentiation of …
(CDK5) and its regulatory protein p35 in nerve growth factor (NGF)-induced differentiation of …