Protein Data Bank (PDB): the single global macromolecular structure archive

SK Burley, HM Berman, GJ Kleywegt… - … : methods and protocols, 2017 - Springer
Abstract The Protein Data Bank (PDB)––the single global repository of experimentally
determined 3D structures of biological macromolecules and their complexes––was …

Cryo-electron microscopy methodology: current aspects and future directions

R Danev, H Yanagisawa, M Kikkawa - Trends in biochemical sciences, 2019 - cell.com
Cryo-electron microscopy (cryo-EM) has emerged as a powerful structure determination
technique. Its most prolific branch is single particle analysis (SPA), a method being used in a …

RCSB Protein Data Bank (RCSB. org): delivery of experimentally-determined PDB structures alongside one million computed structure models of proteins from …

SK Burley, C Bhikadiya, C Bi, S Bittrich… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB), founding member of the Worldwide Protein Data Bank (wwPDB), is the US data center …

Search and sequence analysis tools services from EMBL-EBI in 2022

F Madeira, M Pearce, ARN Tivey… - Nucleic acids …, 2022 - academic.oup.com
The EMBL-EBI search and sequence analysis tools frameworks provide integrated access to
EMBL-EBI's data resources and core bioinformatics analytical tools. EBI Search …

Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures

D Sehnal, S Bittrich, M Deshpande… - Nucleic acids …, 2021 - academic.oup.com
Large biomolecular structures are being determined experimentally on a daily basis using
established techniques such as crystallography and electron microscopy. In addition …

Biological magnetic resonance data bank

JC Hoch, K Baskaran, H Burr, J Chin… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Biological Magnetic Resonance Data Bank (BMRB, https://bmrb. io) is the
international open data repository for biomolecular nuclear magnetic resonance (NMR) …

Automated model building and protein identification in cryo-EM maps

K Jamali, L Käll, R Zhang, A Brown, D Kimanius… - Nature, 2024 - nature.com
Interpreting electron cryo-microscopy (cryo-EM) maps with atomic models requires high
levels of expertise and labour-intensive manual intervention in three-dimensional computer …

UCSF ChimeraX: Structure visualization for researchers, educators, and developers

EF Pettersen, TD Goddard, CC Huang… - Protein …, 2021 - Wiley Online Library
UCSF ChimeraX is the next‐generation interactive visualization program from the Resource
for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX …

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing

R Sanchez-Garcia, J Gomez-Blanco, A Cuervo… - Communications …, 2021 - nature.com
Cryo-EM maps are valuable sources of information for protein structure modeling. However,
due to the loss of contrast at high frequencies, they generally need to be post-processed to …

Data-driven regularization lowers the size barrier of cryo-EM structure determination

D Kimanius, K Jamali, ME Wilkinson, S Lövestam… - Nature …, 2024 - nature.com
Macromolecular structure determination by electron cryo-microscopy (cryo-EM) is limited by
the alignment of noisy images of individual particles. Because smaller particles have weaker …