Oral cancer, primarily oral squamous cell carcinoma (OSCC), continues to be a major global
health problem with high incidence and low survival rates. While the major risk factors for …

DNA is subjected to several modifications, resulting from endogenous and exogenous
sources. The cell has developed a network of complementary DNA-repair mechanisms, and …

Background Polymorphisms in DNA repair genes have been associated to repair DNA
lesions, and might contribute to the individual susceptibility to develop different types of …

Background: Many single nucleotide polymorphisms (SNPs) have been found to be
associated with oral cancer but the biological interactions through SNPs are seldom …

XPC polymorphisms may alter DNA repair capacity, thus leading to genetic instability and
carcinogenesis. Numerous studies have investigated the associations of XPC Lys939Gln …

Objectives To map the genomic pathways of patients with oral leukoplakia (OLK) which
transformed to cancer (progressive) and those which did not (non-progressive), and to …

The X-ray repair cross-complementing group 3 (XRCC3) is a highly suspected candidate
gene for cancer susceptibility. However, association studies on the XRCC3 polymorphisms …

The purpose of this report is to review the relationship between genetic polymorphisms
involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of …

The DNA double strand break repair gene XRCC4, an important caretaker of genome
stability, is suggested to play a role in the development of human carcinogenesis. However …

The aim of this report is to review and evaluate, in a comprehensive manner, the published
data regarding the contribution of genetic polymorphisms to risk of head and neck cancer …