Following fertilization, the two specified gametes must unite to create an entirely new
organism. The genome is initially transcriptionally quiescent, allowing the zygote to be …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …

Plants are highly sensitive to temperature and can perceive a difference of as little as 1° C.
How temperature is sensed and integrated in development is unknown. In a forward genetic …

Knowing the precise locations of nucleosomes in a genome is key to understanding how
genes are regulated. Recent'next generation'ChIP–chip and ChIP–Seq technologies have …

To understand how chromatin structure is organized by different histone variants, we have
measured the genome-wide distribution of nucleosome core particles (NCPs) containing the …

The regulation of eukaryotic chromatin relies on interactions between many epigenetic
factors, including histone modifications, DNA methylation, and the incorporation of histone …

Variation in patterns of methylations of histone tails reflects and modulates chromatin
structure and function. To provide a framework for the analysis of chromatin function in …

RNAi-related pathways regulate diverse processes, from developmental timing to
transposon silencing. Here, we show that in C. elegans the Argonaute CSR-1, the RNA …

Chromatin immunoprecipitation identifies specific interactions between genomic DNA and
proteins, advancing our understanding of gene-level and chromosome-level regulation …