Inflammatory pain is the most common type of pain that is treated clinically. The use of
currently available treatments (classic analgesics-NSAIDs, paracetamol and opioids) is …

The major goal of translational research is to evaluate the efficacy and effectiveness of
treatments and interventions that have emerged from exhaustive preclinical evidence. In …

Background Chronic pain disorders are presumed to induce changes in brain grey and
white matters. Few studies have focused CNS alterations in trigeminal neuralgia (TN) …

This paper is the thirty-sixth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2013 …

Activation of the mu-opioid receptor provides the gold standard for pain relief, but most
opioids used clinically have adverse effects that have contributed to an epidemic of …

Introduction Pain is a common symptom in patients with Guillain–Barre syndrome. Intensity
is moderate to severe in most cases and pain may persist after resolution of the disease …

Abstract Purpose of Review Neuropathic pain is often debilitating, severely limiting the daily
lives of patients who are affected. Typically, neuropathic pain is difficult to manage and, as a …

In the present study, a comprehensive and systematic strategy was described to evaluate
the performance of several three-way calibration methods on a bio-analytical problem …

Postoperative pain control remains an important issue in the field of surgery. Assessing and
managing patients with acute pain who are addicted to opioids are often challenging. It has …

Neuropathic pain remains a clinical challenge due to its complex and not yet fully
understood pathomechanism, which result in limited analgesic effectiveness of the …