Protein kinases play a major role in cellular activation processes, including signal
transduction by diverse immunoreceptors. Given their roles in cell growth and death and in …

Rheumatoid arthritis (RA) is a debilitating autoimmune disorder with an inflammatory
condition targeting the joints that affects millions of patients worldwide. Several unmet needs …

The Janus kinase (JAK) is a master regulator of the JAK/STAT pathway. Dysregulation of this
signalling cascade causes neuroinflammation and autoimmune disorders. Therefore, JAKs …

At the beginning of the last century, multiple pandemics caused by influenza (flu) viruses
severely impacted public health. Despite the development of vaccinations and antiviral …

Target identification and bioactivity prediction are critical steps in the drug discovery
process. Here we introduce CODD-Pred (COmprehensive Drug Design Predictor), an online …

A treasure trove of naturally occurring biomolecules can be obtained from sea living
organisms to be used as potential antioxidant and anti-inflammatory agents. These bioactive …

Dengue virus, a flavivirus that causes dengue shock syndrome and dengue hemorrhagic
fever, is currently prevalent worldwide. A two-component protease (NS2B-NS3) is essential …

The dysfunction of the JAK/STAT (Janus kinase/signal transducers and activators of
transcription) pathway results in several pathophysiological conditions, including …

A computational structure-based drug design approach was employed to identify inhibitors
targeting the active site of the MTHFD2 enzyme. From a virtual screening of 2, 36,561 …

Flavipin, a fungal lower molecular weight biomolecule (MW 196.16 g/mol), has not been yet
extensively studied for beneficial preclinical and clinical applications. In recent years …