Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

The dual role of toll-like receptors in COVID-19: Balancing protective immunity and immunopathogenesis

P Behzadi, D Chandran, C Chakraborty… - International Journal of …, 2024 - Elsevier
Toll-like receptors (TLRs) of human are considered as the most critical immunological
mediators of inflammatory pathogenesis of COVID-19. These immunoregulatory …

The role of toll-like receptors (TLRs) and their related signaling pathways in viral infection and inflammation

R Kircheis, O Planz - International journal of molecular sciences, 2023 - mdpi.com
Toll-like receptors (TLRs) belong to a powerful system for the recognition and elimination of
pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other …

Adjuvants to the S1-subunit of the SARS-CoV-2 spike protein vaccine improve antibody and T cell responses and surrogate neutralization in mice

W Becker, K Rebbani, Z Duan, E Valkov, S Bryant… - Scientific Reports, 2024 - nature.com
Various public health measures have contained outbreaks of SARS-CoV-2, but concerns
remain over the possibility of future surges. Improvements in broadening the vaccine …

Candidate multi-epitope vaccine against Corona B. 1.617 lineage: in silico approach

MG Seadawy, ARN Zekri, AA Saeed, EJ San… - Life, 2022 - mdpi.com
Various mutations have accumulated since the first genome sequence of SARS-CoV2 in
2020. Mutants of the virus carrying the D614G and P681R mutations in the spike protein are …

[HTML][HTML] Differential expression patterns of toll-like receptors in COVID-19 patients

N Lee, R Ko, SY Lee - Frontiers in Bioscience-Landmark, 2023 - imrpress.com
Since Toll-like receptors (TLRs) recognize the earliest signs of infection or cell damage, they
play fundamental roles in innate immunity. This review summarizes the numerous studies on …

Detection of CTLA-4 level and humeral immune response after the second dose of COVID-19 vaccine in certain Iraqi provinces participants

LAIK Al-Kaif, H Al-Ameri, WRO Alfatlawi, AE Mahdi… - Plos one, 2024 - journals.plos.org
Background Evaluating immune responses following COVID-19 vaccination is paramount to
understanding vaccine effectiveness and optimizing public health interventions. This study …

[PDF][PDF] Infection-Simulator, Immunostimulatory and Immunomodulatory Effects of Interferons I and III in Biological Systems: A New Era in Vaccinology and Therapeutics …

TN Carp, M Metoudi, V Ojha - 2024 - preprints.org
The severe acquired respiratory coronavirus–2 (SARS–CoV-2) infection has initiated both
acute and chronic COVID–19 disease between 2020 and 2023, currently evolving with other …

Immunology of SARS-CoV-2 Infection

AG Gabdoulkhakova, RN Mingaleeva… - Biochemistry …, 2024 - Springer
According to the data from the World Health Organization, about 800 million of the world
population had contracted coronavirus infection caused by SARS-CoV-2 by mid-2023 …

Low-Dose Interferon I and III-Based Nasal Sprays: A Good-Looking COVID-19 Vaccine Candidate and a Therapy of the Future?

TN Carp, M Metoudi, B Brown, V Ojha - 2023 - preprints.org
The SARS–CoV-2 infection has caused both acute and chronic COVID–19 disease during
the recent pandemic with emerging more transmissible SARS–CoV–2 Omicron variants …