In the past decade, chimeric antigen receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach for combating cancers, demonstrating remarkable …

Cancer treatment has been advanced with the advent of immune checkpoint inhibitors (ICIs)
exemplified by anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), anti-programmed …

Colorectal cancer (CRC) is the third most diagnosed malignancy and a major leading cause
of cancer-related deaths worldwide. Despite advances in therapeutic regimens, the number …

Colorectal cancer (CRC) is a common and deadly cancer worldwide with a high lethality
rate. Disulfidptosis has been found to be an emerging mode of death in cancer, and the …

Gastric cancer (GC) is one of the most clinically challenging cancers worldwide. Over the
past few years, new molecular-targeted agents and immunotherapy have markedly …

ABSTRACT N4-acetylcytidine (ac4C) is one type of RNA modification found in eukaryotes.
RNA acetylation modifications are gradually expanding in oncology. However, the role of …

Metastasis of colorectal cancer (CRC) is a leading cause of mortality among CRC patients.
Elevated COX-2 and PD-L1 expression in colon cancer tissue has been linked to distant …

Introduction Acid ceramidase (hereafter referred as ASAH1) is an enzyme in sphingolipid
metabolism that converts pro-survival ceramide into sphingosine. ASAH1 has been shown …

Simple Summary Identification of novel molecular markers of pathological complete
response (pCR) to preoperative radiation-based therapy in locally advanced rectal cancer …

The American Society of Colon and Rectal Surgeons (ASCRS) is dedicated to ensuring
highquality patient care by advancing the science, prevention, and management of …