The hepatitis delta virus: Replication and pathogenesis

C Sureau, F Negro - Journal of hepatology, 2016 - Elsevier
Hepatitis delta virus (HDV) is a defective virus and a satellite of the hepatitis B virus (HBV).
Its RNA genome is unique among animal viruses, but it shares common features with some …

Hepatitis delta virus

SA Hughes, H Wedemeyer, PM Harrison - The Lancet, 2011 - thelancet.com
Hepatitis delta virus (HDV) is a small, defective RNA virus that can infect only individuals
who have hepatitis B virus (HBV); worldwide more than 15 million people are co-infected …

Origin, HDV genotype and persistent viremia determine outcome and treatment response in patients with chronic hepatitis delta

D Roulot, S Brichler, R Layese, Z BenAbdesselam… - Journal of …, 2020 - Elsevier
Background & Aims HDV infection causes severe chronic liver disease in individuals
infected with HBV. However, the factors associated with poor prognosis are largely …

Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial

C Koh, L Canini, H Dahari, X Zhao… - The Lancet Infectious …, 2015 - thelancet.com
Background Therapies for chronic hepatitis delta virus (HDV) infection are unsatisfactory.
Prenylation is essential for HDV and inhibition abrogates HDV production in experimental …

Peginterferon plus adefovir versus either drug alone for hepatitis delta

H Wedemeyer, C Yurdaydìn, GN Dalekos… - … England Journal of …, 2011 - Mass Medical Soc
Background Chronic infection with hepatitis B virus and hepatitis delta virus (HDV) results in
the most severe form of viral hepatitis. There is no currently approved treatment. We …

Epidemiology, pathogenesis and management of hepatitis D: update and challenges ahead

H Wedemeyer, MP Manns - Nature reviews Gastroenterology & …, 2010 - nature.com
Hepatitis D is caused by infection with the hepatitis D virus (HDV) and is considered to be
the most severe form of viral hepatitis in humans. Hepatitis D occurs only in individuals …

[HTML][HTML] KASL clinical practice guidelines: management of hepatitis C

Korean Association for the Study of the … - Clinical and …, 2016 - ncbi.nlm.nih.gov
Aims The Korean Association for the Study of the Liver (KASL) Practice Guidelines for
Management of Hepatitis C were first established in 2004, and revised in 2013, when direct …

[PDF][PDF] Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages

X Cheng, Y Xia, E Serti, PD Block, M Chung… - …, 2017 - Wiley Online Library
Hepatitis B virus (HBV) infects hepatocytes specifically and causes immune‐mediated liver
damage. How HBV interacts with the innate immunity at the early phase of infection, either …

Clinical features of hepatitis D

P Farci, GA Niro - Seminars in liver disease, 2012 - thieme-connect.com
Hepatitis D is caused by infection with hepatitis D virus (HDV), a defective RNA virus that
requires the obligatory helper function of hepatitis B virus (HBV) for its in vivo transmission …

Treating chronic hepatitis delta: the need for surrogate markers of treatment efficacy

C Yurdaydin, Z Abbas, M Buti, M Cornberg… - Journal of …, 2019 - Elsevier
Chronic hepatitis delta represents the most severe form of chronic viral hepatitis. The current
treatment of hepatitis delta virus (HDV) infection consists of the use of interferons and is …