Exercise metabolism and adaptation in skeletal muscle

JAB Smith, KA Murach, KA Dyar… - Nature Reviews Molecular …, 2023 - nature.com
Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia

L Sylow, VL Tokarz, EA Richter, A Klip - Cell Metabolism, 2021 - cell.com
As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock

DM Muoio - Cell, 2014 - cell.com
Normal energy metabolism is characterized by periodic shifts in glucose and fat oxidation,
as the mitochondrial machinery responsible for carbon combustion switches freely between …

Fatty acid activation in carcinogenesis and cancer development: Essential roles of long-chain acyl-CoA synthetases

Y Tang, J Zhou, SC Hooi, YM Jiang… - Oncology …, 2018 - spandidos-publications.com
The significance of fatty acid metabolism in cancer initiation and development is increasingly
accepted by scientists and the public due to the high prevalence of overweight and obese …

Molecular regulation of fatty acid oxidation in skeletal muscle during aerobic exercise

AM Lundsgaard, AM Fritzen, B Kiens - Trends in Endocrinology & …, 2018 - cell.com
This review summarizes how fatty acid (FA) oxidation is regulated in skeletal muscle during
exercise. From the available evidence it seems that acetyl-CoA availability in the …

Stress biomarkers and proteomics alteration to thermal stress in ruminants: A review

SA Abdelnour, ME Abd El-Hack, AF Khafaga… - Journal of thermal …, 2019 - Elsevier
Heat stress may adversely affect physiochemical and immune responses of livestock and
alter biological functions. The comfort or thermoneutral zone for livestock, which has long …

TANK-binding kinase 1 regulates the localization of acyl-CoA synthetase ACSL1 to control hepatic fatty acid oxidation

JY Huh, SM Reilly, M Abu-Odeh, AN Murphy… - Cell metabolism, 2020 - cell.com
Hepatic TANK (TRAF family member associated NFκB activator)-binding kinase 1 (TBK1)
activity is increased during obesity, and administration of a TBK1 inhibitor reduces fatty liver …

Systematic analysis of gene expression alterations and clinical outcomes for long-chain acyl-coenzyme A synthetase family in cancer

WC Chen, CY Wang, YH Hung, TY Weng, MC Yen… - PloS one, 2016 - journals.plos.org
Dysregulated lipid metabolism contributes to cancer progression. Our previous study
indicates that long-chain fatty acyl-Co A synthetase (ACSL) 3 is essential for lipid …

Metabolomic analysis of primary human skeletal muscle cells during myogenic progression

A Kumar, Y Kumar, JK Sevak, S Kumar, N Kumar… - Scientific Reports, 2020 - nature.com
Skeletal muscle constitutes more than 30% of total body mass using substrates such as
glycogen, glucose, free fatty acids, and creatinine phosphate to generate energy …

Integrated metabolomics study of the milk of heat-stressed lactating dairy cows

H Tian, N Zheng, W Wang, J Cheng, S Li, Y Zhang… - Scientific reports, 2016 - nature.com
Heat stress (HS) damages the global dairy industry by reducing milk yields and quality,
harming health, and damaging the reproduction of dairy cows, causing huge economic …