The blood–brain barrier (BBB) is a cellular and physical barrier with a crucial role in
homeostasis of the brain extracellular environment. It controls the imports of nutrients to the …

SLC38A5/SNAT5 is a system N transporter that can mediate net inward or outward
transmembrane fluxes of neutral amino acids coupled with Na+ (symport) and H+ (antiport) …

Endothelial cells represent the first biological barrier for compounds, including
nanoparticles, administered via the intravascular route. In the case of ischemic stroke and …

Proteomics refers to the large-scale study of proteins, providing comprehensive and
quantitative information on proteins in tissue, blood, and cell samples. In many studies …

Purpose The insulin receptor (INSR) mediates insulin signaling to modulate cellular
functions. Although INSR is expressed at the blood–brain barrier (BBB), its role in the …

The blood-brain barrier (BBB) prevents the permeability of drugs into the brain, and as such
limits the management of various brain diseases. To overcome this barrier, drug …

L-type amino acid transporter 1 (LAT1) is integral to the transport of large neutral amino
acids across the blood–brain barrier (BBB), playing a crucial role in brain homeostasis and …

Interrogation of the molecular makeup of the blood–brain barrier (BBB) using proteomic
techniques has contributed to the cataloguing and functional understanding of the proteins …

Cell-surface proteins that can endocytose into brain microvascular endothelial cells serve as
promising candidates for receptor-mediated transcytosis across the blood–brain barrier …

Membrane proteins mediate various biological processes. Most drugs commercially
available target proteins on the cell surface. Therefore, proteomics of plasma membrane …