Peripheral tissue damage or nerve injury often leads to pathological pain processes, such
as spontaneous pain, hyperalgesia and allodynia, that persist for years or decades after all …

1. Introduction......................................... II. Anatomy and physiology................................ A. The
peripheral apparatus............................. Fiber composition of muscle nerves …

Calcitonin gene‐related peptide (CGRP) is a key mediator in primary headaches including
migraine. Animal models of meningeal nociception demonstrate both peripheral and central …

Gabapentin and pregabalin are amino acid derivatives of γ-amino butyric acid that have
anticonvulsant, analgesic, and anxiolytic-like properties in animal models. The mechanisms …

Peptides released in the spinal cord from the central terminals of nociceptors contribute to
the persistent hyperalgesia that defines the clinical experience of chronic pain. Using …

The responses to excitatory and inhibitory amino acids and peptides were investigated in
isolated rat spinal dorsal horn neurons (laminae I–V) of young rats using the whole-cell …

Migraine is among the most common types of pain, but its mechanisms are poorly
understood. A growing body of evidence points to a critical role of calcitonin gene–related …

An immunocytochemical double labelling study of L4 dorsal root ganglia from rats aged
seven to 10 weeks was made with an antibody to calcitonin gene-related peptide and with …

Arthritis is the commonest cause of disabling chronic pain, and both osteoarthritis (OA) and
rheumatoid arthritis (RA) remain major burdens on both individuals and society. Peripheral …

Peripheral inflammation induced with a knee joint injection of a mixture of
kaolin/carrageenan (k/c) produces primary and secondary hyperalgesia. Inflammatory pain …