Introduction Protective and destructive immunoreactions take place simultaneously in apical
periodontitis. However, the same reactions defending the periapical area from infection …

During the last decade it has become clear that periodontal ligament fibroblasts may
contribute to the in vitro differentiation of osteoclasts. We surveyed the current findings …

Chronic inflammatory diseases, such as rheumatoid arthritis and periodontitis, are the most
common causes of bone tissue destruction. Recently, human periodontal ligament tissue …

Periodontitis represents a complex inflammatory disease that compromises the integrity of
the tooth-supporting tissue through the interaction of specific periodontal pathogens and the …

Inflammation is the tissues' defense response after the body is stimulated by microbial
infection or damage signals, and it is initiated when pattern recognition receptors recognize …

The periodontal ligament (PDL) is a key contributor to the process of regeneration of the
periodontium. The heterogeneous nature of the PDL tissue, its development during early …

Scheres N, Laine ML, Sipos PM, Bosch‐Tijhof CJ, Crielaard W, de Vries TJ, Everts V.
Periodontal ligament and gingival fibroblasts from periodontitis patients are more active in …

Recent evidence emphasized that transglutaminase 2 (TG2), a protein cross-linking
enzyme, may play a role in the early phase of inflammation. High levels of TG2 have been …

Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) can induce the host
immune response in periodontitis patients. Human gingival fibroblasts (GFs) play an …

Objective: Ferritin, an iron-binding protein, is ubiquitous and highly conserved; it plays a
crucial role in inflammation, which is the main symptom of periodontitis. Full-length cDNA …