Alcohol is a major contributor to global disease and a leading cause of preventable death,
causing approximately 88,000 deaths annually in the United States alone. Alcohol use …

A relapsing-remitting course is very common in patients with an Alcohol Use Disorder
(AUD). Understanding the determinants associated with alcohol resumption remains a …

Depression is one of the most prevalent forms of mental disorders and is the most common
cause of disability in the Western world. Besides, the harmful effects of stress-related mood …

Major depression, with its strikingly high prevalence, is the most common cause of disability
in communities of Western type, according to data of the World Health Organization. Stress …

Stress is commonly regarded as an important trigger for relapse and a significant factor that
promotes increased motivation to drink in some individuals. However, the relationship …

Aims Nuclear factor kappa light chain enhancer of activated B cells (NFkB) is a ubiquitous
transcription factor well known for its role in the innate immune response. As such, NFkB is a …

Until very recently addiction-research was limited by existing tools and strategies that were
inadequate for studying the inherent complexity at each of the different phenomenological …

Post‐traumatic stress disorder (PTSD) and alcohol‐use disorder (AUD) are highly comorbid
in humans. Although we have some understanding of the structural and functional brain …

Alcohol is frequently consumed for stress relief, but the individual determinants and the
temporal course of stress-induced alcohol use are not well understood. Preclinical studies …

Drug addiction is a progressive, relapsing disease comprised of interlocking stages of
disordered motivation. Numerous animal models describing various stages of the addiction …