[HTML][HTML] HELLP syndrome—holistic insight into pathophysiology

A Petca, BC Miron, I Pacu, MC Dumitrașcu… - Medicina, 2022 - mdpi.com
HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and
low platelets, represents a severe pregnancy complication typically associated with …

Myostatin/activin pathway antagonism: molecular basis and therapeutic potential

HQ Han, X Zhou, WE Mitch, AL Goldberg - The international journal of …, 2013 - Elsevier
Muscle wasting is associated with a wide range of catabolic diseases. This debilitating loss
of muscle mass and functional capacity reduces the quality of life and increases the risks of …

Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications

P Ciarmela, MS Islam, FM Reis, PC Gray… - Human reproduction …, 2011 - academic.oup.com
BACKGROUND Growth factors are proteins secreted by a number of cell types that are
capable of modulating cellular growth, proliferation and cellular differentiation. It is well …

Applications of chondrocyte‐based cartilage engineering: an overview

AR Phull, SH Eo, Q Abbas, M Ahmed… - BioMed research …, 2016 - Wiley Online Library
Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of
cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and …

TGFBR3L is an inhibin B co-receptor that regulates female fertility

E Brûlé, Y Wang, Y Li, YF Lin, X Zhou, L Ongaro… - Science …, 2021 - science.org
Follicle-stimulating hormone (FSH), a key regulator of ovarian function, is often used in
infertility treatment. Gonadal inhibins suppress FSH synthesis by pituitary gonadotrope cells …

The activins and their binding protein, follistatin—diagnostic and therapeutic targets in inflammatory disease and fibrosis

MP Hedger, DM de Kretser - Cytokine & growth factor reviews, 2013 - Elsevier
The activins, as members of the transforming growth factor-β superfamily, are pleiotrophic
regulators of cell development and function, including cells of the myeloid and lymphoid …

[HTML][HTML] HS, an ancient molecular recognition and information storage glycosaminoglycan, equips hs-proteoglycans with diverse matrix and cell-interactive properties …

AJ Hayes, J Melrose - International Journal of Molecular Sciences, 2023 - mdpi.com
Heparan sulfate is a ubiquitous, variably sulfated interactive glycosaminoglycan that
consists of repeating disaccharides of glucuronic acid and glucosamine that are subject to a …

[HTML][HTML] Cancer treatment and bone health

C Handforth, S D'Oronzo, R Coleman… - Calcified tissue …, 2018 - Springer
Considerable advances in oncology over recent decades have led to improved survival,
while raising concerns about long-term consequences of anticancer treatments. In patients …

Reproductive endocrinology of vitamin D

M Lorenzen, IM Boisen, LJ Mortensen, B Lanske… - Molecular and cellular …, 2017 - Elsevier
Vitamin D is a versatile hormone with several functions beyond its well-established role in
maintenance of skeletal health and calcium homeostasis. The effects of vitamin D are …

[HTML][HTML] Neural tissue homeostasis and repair is regulated via CS and DS proteoglycan motifs

AJ Hayes, J Melrose - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Chondroitin sulfate (CS) is the most abundant and widely distributed glycosaminoglycan
(GAG) in the human body. As a component of proteoglycans (PGs) it has numerous roles in …